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TDP-43 toxicity and the usefulness of junk

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A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

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Figure 1: Model for suppression of TDP-43 toxicity following loss of Dbr1.

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Authors and Affiliations

  1. Shuying Sun and Don W. Cleveland are at the Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, USA.,

    Shuying Sun & Don W Cleveland

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  1. Shuying Sun
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  2. Don W Cleveland
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Correspondence to Don W Cleveland.

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The authors declare no competing financial interests.

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Sun, S., Cleveland, D. TDP-43 toxicity and the usefulness of junk. Nat Genet 44, 1289–1291 (2012). https://doi.org/10.1038/ng.2473

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