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Tracking the evolution of cancer methylomes

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Cellular transformation in cancer has long been associated with aberrant DNA methylation, most notably, hypermethylation of promoter sequences. A new study uses a clever approach of selective high-resolution profiling to follow DNA methylation over a time course of cellular transformation and challenges the notion that hypermethylation in cancer arises in an orchestrated fashion.

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Figure 1: The ability to detect polymorphic methylation patterns depends on the depth of coverage with which a particular region is sequenced.

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Authors and Affiliations

  1. Arnaud R. Krebs and Dirk Schübeler are at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.,

    Arnaud R Krebs & Dirk Schübeler

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  1. Arnaud R Krebs
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  2. Dirk Schübeler
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Correspondence to Dirk Schübeler.

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The authors declare no competing financial interests.

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Krebs, A., Schübeler, D. Tracking the evolution of cancer methylomes. Nat Genet 44, 1173–1174 (2012). https://doi.org/10.1038/ng.2451

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