Neuroendocrine cells, including those in the gut, have a vast array of functions. A new study shows that conditional inactivation of the gene encoding Foxo1 in mouse intestinal endocrine cells converts them into cells synthesizing and secreting insulin. Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic β-cell loss and diabetes mellitus.
References
Ferber, S. et al. Nat. Med. 6, 568–572 (2000).
Yechoor, V. et al. Dev. Cell 16, 358–373 (2009).
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D.A. Nature 455, 627–632 (2008).
Thorel, F. et al. Nature 464, 1149–1154 (2010).
Cheung, A.T. et al. Science 290, 1959–1962 (2000).
Talchai, C., Xuan, S., Kitamura, T., DePinho, R.A. & Accili, D. Nat. Genet. 44, 406–412 (2012).
Gradwohl, G., Dierich, A., LeMeur, M. & Guillemot, F. Proc. Natl. Acad. Sci. USA 97, 1607–1611 (2000).
Lee, C.S., Perreault, N., Brestelli, J.E. & Kaestner, K.H. Genes Dev. 16, 1488–1497 (2002).
Wang, J. et al. N. Engl. J. Med. 355, 270–280 (2006).
May, C.L. & Kaestner, K.H. Mol. Cell. Endocrinol. 323, 70–75 (2010).
Benitez, C., Goodyer, W.R. & Kim, S.K. (Cold Spring Harbor Press, in the press).
Miguel-Aliaga, I., Thor, S. & Gould, A.P. PLoS Biol. 6, e58 (2008).
Park, S., Bustamante, E.L., Antonova, J., McLean, G.W. & Kim, S.K. PLoS Genet. 7, e1002241 (2011).
Lee, G. & Park, J.H. Genetics 167, 311–323 (2004).
Murphy, C.T., Lee, S.J. & Kenyon, C. Proc. Natl. Acad. Sci. USA 104, 19046–19050 (2007).
Conlon, J.M., Reinecke, M., Thorndyke, M.C. & Falkmer, S. Horm. Metab. Res. 20, 406–410 (1988).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Kim, S. Gut insulin from Foxo1 loss. Nat Genet 44, 363–364 (2012). https://doi.org/10.1038/ng.2226
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.2226
- Springer Nature America, Inc.