DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
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Trowbridge, J., Orkin, S. Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet 44, 13–14 (2012). https://doi.org/10.1038/ng.1043
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DOI: https://doi.org/10.1038/ng.1043
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