Skip to main content

Advertisement

Log in

Focal and generalized bone loss in rheumatoid arthritis: separate or similar concepts?

  • Viewpoint
  • Published:

From Nature Clinical Practice Rheumatology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Sambrook PN (2000) The skeleton in rheumatoid arthritis: common mechanisms for bone erosion and osteoporosis? J Rheumatol 27: 2541–2542

    CAS  PubMed  Google Scholar 

  2. Redlich K et al. (2002) Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest 110: 1419–1427

    Article  CAS  Google Scholar 

  3. Pettit AR et al. (2001) TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159: 1689–1699

    Article  CAS  Google Scholar 

  4. Jarrett SJ et al. (2006) Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis. Arthritis Rheum 54: 1410–1414

    Article  CAS  Google Scholar 

  5. Schett G et al. (2005) Mechanisms of Disease: the link between RANKL and arthritic bone disease. Nat Clin Pract Rheumatol 1: 47–54

    Article  CAS  Google Scholar 

  6. Vis M et al. (2006) Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFkappaB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis. Ann Rheum Dis 65: 1495–1499

    Article  CAS  Google Scholar 

  7. Hoff M et al. (2007) Anti-TNF treatment with adalimumab reduces hand bone loss in early rheumatoid arthritis (RA): explorative analyses from the PREMIER study [abstract #268]. Arthritis Rheum 56 (Suppl): S152–S153. Presented at the ACR/ARHP Annual Scientific Meeting: 2007 November 6–11, Boston, MA

    Google Scholar 

  8. Breedveld FC et al. (2006) The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 54: 26–37

    Article  CAS  Google Scholar 

  9. Haugeberg G et al. (2005) Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis: results from a randomized placebo-controlled trial. Arch Intern Med 165: 1293–1297

    Article  Google Scholar 

  10. van der Heijde D et al. (2007) Denosumab inhibits RANKL, reducing progression of the total Sharp score and bone erosions in patients with rheumatoid arthritis: 12-month X-ray results [abstract #698]. Arthritis Rheum 56 (Suppl): S299–S300. Presented at the ACR/ARHP Annual Scientific Meeting: 2007 November 6–11, Boston, MA

    Google Scholar 

  11. Haugeberg G and Emery P (2005) Value of dual-energy X-ray absorptiometry as a diagnostic and assessment tool in early rheumatoid arthritis. Rheum Dis Clin North Am 31: 715–728

    Article  Google Scholar 

  12. Haugeberg G et al. (2006) Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis. Ann Rheum Dis 65: 736–740

    Article  CAS  Google Scholar 

  13. Hoff M et al. (2008) Cortical hand bone loss after one year in early rheumatoid arthritis predicts radiographic hand joint damage at 5 and 10 year follow-up. Ann Rheum Dis [10.1136/ard.2007.085985]

  14. Haugeberg G et al. (2007) Hand bone densitometry: a more sensitive standard for the assessment of early bone damage in rheumatoid arthritis. Ann Rheum Dis 66: 1513–1517

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haugeberg, G. Focal and generalized bone loss in rheumatoid arthritis: separate or similar concepts?. Nat Rev Rheumatol 4, 402–403 (2008). https://doi.org/10.1038/ncprheum0843

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncprheum0843

  • Springer Nature Limited

This article is cited by

Navigation