Skip to main content
SpringerLink
Log in

Prophylactic surgery prevents endometrial and ovarian cancer in Lynch syndrome

  • Viewpoint
  • Published:

From Nature Clinical Practice Oncology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lynch HT et al. (1966) Hereditary factors in cancer: study of two large Midwestern kindreds. Arch Intern Med 117: 206–212

    Article  CAS  Google Scholar 

  2. Lynch HT et al. (2006) Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet 14: 390–402

    Article  CAS  Google Scholar 

  3. Vasen HFA et al. (1996) Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 110: 1020–1027

    Article  CAS  Google Scholar 

  4. Quehenberger F et al. (2005) Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment. J Med Genet 42: 491–496

    Article  CAS  Google Scholar 

  5. Schmeler KM et al. (2006) Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome. N Engl J Med 354: 261–269

    Article  CAS  Google Scholar 

  6. Lu KH et al. (2005) Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal cancer syndrome. Obstet Gynecol 105: 569–574

    Article  Google Scholar 

  7. Watson P et al. (2001) The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol 82: 223–228

    Article  CAS  Google Scholar 

  8. Rijcken FE et al. (2003) Gynecologic screening in hereditary nonpolyposis colorectal cancer. Gynecol Oncol 91: 74–80

    Article  Google Scholar 

  9. Lynch HT et al. (1977) Proximal colon cancer in familial carcinoma of the colon exclusive of familial polyposis coli. Lancet 1: 1306–1307

    Article  CAS  Google Scholar 

  10. Renkonen-Sinisalo L et al. (2007) Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome. Int J Cancer 120: 821–824

    Article  CAS  Google Scholar 

  11. Lynch HT et al. (1982) Surveillance and management of patients at high genetic risk for ovarian carcinoma. Obstet Gynecol 59: 589–596

    CAS  PubMed  Google Scholar 

  12. Casey MJ et al. (1995) Laparoscopic examination and assisted bilateral salpingo-oophorectomy hysterectomy for prophylactic removal of the ovaries and uterus in women at genetic risk for ovarian cancer. J Gynecol Tech 1: 111–114

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. HT Lynch is Professor of Medicine and Chair of the Department of Preventive Medicine and Public Health and MJ Casey is Professor of Obstetrics and Gynecology and Director of Gynecologic Oncology at Creighton University School of Medicine, Omaha, NE, USA.,

    Henry T Lynch & Murray Joseph Casey

Authors
  1. Henry T Lynch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Murray Joseph Casey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henry T Lynch.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lynch, H., Casey, M. Prophylactic surgery prevents endometrial and ovarian cancer in Lynch syndrome. Nat Rev Clin Oncol 4, 672–673 (2007). https://doi.org/10.1038/ncponc1002

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc1002

  • Springer Nature Limited

This article is cited by

Search

Navigation