Skip to main content

Advertisement

SpringerLink
Log in

The clinical significance of circulating tumor cells

  • Viewpoint
  • Published:

From Nature Clinical Practice Oncology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kang Y et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537–549

    Article  CAS  Google Scholar 

  2. Minn AJ et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436: 518–524

    Article  CAS  Google Scholar 

  3. Pantel K and Brakenhoff R (2004) Dissecting the metastatic cascade. Nat Rev Cancer 4: 448–456

    Article  CAS  Google Scholar 

  4. Braun S et al. (2005) A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 353: 793–802

    Article  CAS  Google Scholar 

  5. Meng S et al. (2004) Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 10: 8152–8162

    Article  Google Scholar 

  6. Solakoglu O et al. (2002) Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors. Proc Natl Acad Sci USA 99: 2246–2251

    Article  CAS  Google Scholar 

  7. Alix-Panabières C et al. : Detection and characterization of putative metastatic precursor cells in cancer patients. Clin Chem, in press

  8. Gudjonsson T et al. (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev 16: 693–706

    Article  CAS  Google Scholar 

  9. Zach O and Lutz D (2006) Tumor cell detection in peripheral blood and bone marrow. Curr Opin Oncol 18: 48–56

    Article  Google Scholar 

  10. Cristofanilli M et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781–791

    Article  CAS  Google Scholar 

  11. Cristofanilli M and Mendelsohn J (2006) Circulating tumor cells in breast cancer: advanced tools for “tailored” therapy? Proc Natl Acad Sci USA 103: 17073–17074

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge grant support from the European Commission (DISMALproject, contract No. LSHCCT- 2005-018911), Deutsche Forschungsgemeinschaft (PA341/15-2), and Deutsche Krebshilfe (10-2181-Pa2). Competing interests

Author information

Author notes

  1. C Alix-Panabières is a cellular biologist in the Immuno-Virology Department of the Lapeyronie Hospital at the University Medical Centre of Montpellier, Montpellier, France.

Authors and Affiliations

  1. K Pantel is Professor of Tumour Biology and Chairman of the Institute of Tumour Biology at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany,,

    Klaus Pantel & Catherine Alix-Panabières

Authors
  1. Klaus Pantel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Catherine Alix-Panabières
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Klaus Pantel.

Ethics declarations

Competing interests

K Pantel has received a research grant from Veridex, USA (the distributor of the CellSearch™ system). C Alix-Panabières declared she has no competing interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pantel, K., Alix-Panabières, C. The clinical significance of circulating tumor cells. Nat Rev Clin Oncol 4, 62–63 (2007). https://doi.org/10.1038/ncponc0737

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc0737

  • Springer Nature Limited

This article is cited by

Search

Navigation