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When is a genomic classifier ready for prime time?

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References

  1. Rosenwald A et al. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N Engl J Med 346: 1937–1947

    Article  Google Scholar 

  2. Hilsenbeck SG et al. (1992) Why do so many prognostic factors fail to pan out? Breast Cancer Res Treat 22: 197–206

    Article  CAS  Google Scholar 

  3. Hayes DF et al. (1998) Assessing the clinical impact of prognostic factors: when is “statistically significant” clinically useful? Breast Cancer Res Treat 52: 304–319

    Article  Google Scholar 

  4. Simon R and Altman DG (1994) Statistical aspects of prognostic factor studies in oncology. Br J Cancer 69: 979–985

    Article  CAS  Google Scholar 

  5. Simon R et al. (2003) Pitfalls in the analysis of DNA microarray data: class prediction methods. J Natl Cancer Inst 95: 14–18

    Article  CAS  Google Scholar 

  6. Hastie T et al. (2001) The Elements of Statistical Learning. New York: Springer

    Book  Google Scholar 

  7. Simon R (2003) Diagnostic and prognostic prediction using gene expression profiles in high dimensional microarray data. Br J Cancer 89: 1599–1604

    Article  CAS  Google Scholar 

  8. Simon RM et al. (2003) Design and Analysis of DNA Microarray Investigations. New York: Springer

    Google Scholar 

  9. Covinsky JA and Berlin JE (1999) Assessing the generalizability of prognostic information. Ann Intern Med 130: 515–524

    Article  Google Scholar 

  10. Pepe MS (2003) The statistical evaluation of medical tests for classification and prediction. Oxford: Oxford University Press

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Correspondence to Richard Simon.

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Simon, R. When is a genomic classifier ready for prime time?. Nat Rev Clin Oncol 1, 4–5 (2004). https://doi.org/10.1038/ncponc0006

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