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Chemical genetic modification of Ca2+ channel activity

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Pharmacological and genetic modulators of voltage-gated Ca2+ channel (CaV) activity have been useful tools for understanding and modulating excitable cell function. A new method combines these approaches to provide pharmacological control of a genetically encoded suppressor of CaV activity.

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Figure 1: Rapamycin-dependent suppression of Cav activity.

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, Michael Nitabach is in the Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA. michael.nitabach@yale.edu,

    Michael Nitabach

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  1. Michael Nitabach
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Nitabach, M. Chemical genetic modification of Ca2+ channel activity. Nat Chem Biol 3, 754–755 (2007). https://doi.org/10.1038/nchembio1207-754

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  • DOI: https://doi.org/10.1038/nchembio1207-754

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