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NO link between calorie restriction and mitochondria

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Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.

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Figure 1: In white adipose tissue and other mouse tissues, caloric restriction (CR) induces cGMP production through an increase in eNOS levels.

Rebecca Henretta

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  1. Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA

    Leonard Guarente

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  1. Leonard Guarente
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Guarente, L. NO link between calorie restriction and mitochondria. Nat Chem Biol 1, 355–356 (2005). https://doi.org/10.1038/nchembio1205-355

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