Skip to main content
SpringerLink
Log in

S-nitrosylation TRiPs a calcium switch

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Accumulating evidence indicates that protein S-nitrosylation may convey a broad spectrum of cellular signals. S-nitrosylation of critical cysteine thiols activates a subset of cation-permeable, transient receptor potential channel proteins (TRPs), which may represent a general mechanism for regulating stimulus-coupled cellular Ca2+ flux.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: An S-nitrosylation–based signaling module for eNOS.

Katie Ris

References

  1. Stamler, J.S., Lamas, S. & Fang, F.C. Cell 106, 675–683 (2001).

    Article  CAS  Google Scholar 

  2. Hess, D.T., Matsumoto, A., Kim, S.O., Marshall, H.E. & Stamler, J.S. Nat. Rev. Mol. Cell Biol. 6, 150–166 (2005).

    Article  CAS  Google Scholar 

  3. Rhee, S.G. Science 312, 1882–1883 (2006).

    Article  Google Scholar 

  4. Yoshida, T. et al. Nat. Chem. Biol. 2, 596–607 (2006).

    Article  CAS  Google Scholar 

  5. Stamler, J.S. & Meissner, G. Physiol. Rev. 81, 209–237 (2001).

    Article  CAS  Google Scholar 

  6. Lipton, S.A. et al. Trends Neurosci. 25, 474–480 (2002).

    Article  CAS  Google Scholar 

  7. Montrell, C. Sci. STKE 2005, re3 (2005).

    Google Scholar 

  8. Miller, B.A. J. Membr. Biol. 209, 31–41 (2006).

    Article  CAS  Google Scholar 

  9. Jung, S. et al. J. Biol. Chem. 278, 3562–3571 (2003).

    Article  CAS  Google Scholar 

  10. Dudzinski, D.M., Igarashi, J., Greif, D. & Michel, T. Annu. Rev. Pharmacol. Toxicol. 46, 235–276 (2006).

    Article  CAS  Google Scholar 

  11. Crousillac, S., LeRouge, M., Rankin, M. & Gleason, E. Vis. Neurosci. 20, 453–463 (2003).

    Article  Google Scholar 

  12. Freichel, M. et al. Nat. Cell Biol. 3, 121–127 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Matthew W Foster & Douglas T Hess

  2. the Department of Medicine and the Department of Biochemistry, Box 2612, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Jonathan S Stamler

Authors
  1. Matthew W Foster
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Douglas T Hess
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jonathan S Stamler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Foster, M., Hess, D. & Stamler, J. S-nitrosylation TRiPs a calcium switch. Nat Chem Biol 2, 570–571 (2006). https://doi.org/10.1038/nchembio1106-570

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio1106-570

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation