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Sugars stack up

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Sugar binding by a variety of biomolecules is generally assumed to rely on hydrogen bonding and ionic interactions. A new study shows that arene-carbohydrate interactions are enthalpically driven through nontraditional C-H···π type hydrogen bonds.

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Figure 1: The dangling-end model system uses the stability of a DNA duplex to investigate the arene-carbohydrate interaction.

Katie Ris-Vicari

References

  1. Varki, A. Glycobiology 3, 97–130 (1993).

    Article  CAS  Google Scholar 

  2. Gabius, H.J., Siebert, H.C., André, S., Jiménez-Barbero, J. & Rüdiger, H. ChemBioChem 5, 740–764 (2004).

    Article  CAS  Google Scholar 

  3. Morales, J. et al. Chem. Eur. J. published online, 10.1002/chem.200800335 (21 July 2008).

  4. Forst, D., Welte, W., Wacker, T. & Diederichs, K. Nat. Struct. Biol. 5, 37–46 (1998).

    Article  CAS  Google Scholar 

  5. Weis, W.I. & Drickamer, K. Annu. Rev. Biochem. 65, 441–473 (1996).

    Article  CAS  Google Scholar 

  6. Orlik, F., Andersen, C. & Benz, R. Biophys. J. 83, 309–321 (2002).

    Article  CAS  Google Scholar 

  7. Senior, M., Jones, R. & Breslauer, K. Biochemistry 27, 3879–3885 (1988).

    Article  CAS  Google Scholar 

  8. Kiehna, S., Laughrey, Z. & Waters, M. Chem. Commun. (Camb.) 39, 4026–4028 (2007).

    Article  Google Scholar 

  9. del Carmen Fernández-Alonso, M., Cañada, F., Jiménez-Barbero, J. & Cuevas, G. J. Am. Chem. Soc. 127, 7379–7386 (2005).

    Article  Google Scholar 

  10. Bänteli, R. et al. Helv. Chim. Acta 83, 2893–2907 (2000).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Chad Tatko is in the Department of Chemistry and Biochemistry, Calvin College, 3201 Burton Street, Grand Rapids, Michigan 49546, USA. cdt2@calvin.edu,

    Chad Tatko

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  1. Chad Tatko
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Tatko, C. Sugars stack up. Nat Chem Biol 4, 586–587 (2008). https://doi.org/10.1038/nchembio1008-586

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  • DOI: https://doi.org/10.1038/nchembio1008-586

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