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Breaking the silence in Friedreich's ataxia

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A histone deacetylase inhibitor seems to restore the transcriptional activity of a silenced gene by overcoming heterochromatin effects, thereby offering a potential treatment for the neurodegenerative disease Friedreich's ataxia.

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Figure 1: Putative pathway whereby the new HDAC inhibitor may reverse silencing in cells from people with Friedreich's ataxia.

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Authors and Affiliations

  1. Chair of the Section of Experimental Physiology and Medicine, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK

    Richard Festenstein

  2. Consultant in Neurogenetics, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK

    Richard Festenstein

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  1. Richard Festenstein
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Festenstein, R. Breaking the silence in Friedreich's ataxia. Nat Chem Biol 2, 512–513 (2006). https://doi.org/10.1038/nchembio1006-512

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