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Lox and Cre sandwich

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Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre recombinase accomplishes this catalytic feat.

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Figure 1: The Cre recombination reaction.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, 94720-3202, California

    Linda Lee

  2. Department of Molecular and Medical Genetics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Paul D Sadowski

Authors
  1. Linda Lee
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  2. Paul D Sadowski
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Lee, L., Sadowski, P. Lox and Cre sandwich. Nat Chem Biol 1, 246–247 (2005). https://doi.org/10.1038/nchembio1005-246

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