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Decoding chemical structures from genomes

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Coelichelin is a new tetrapeptide siderophore from Streptomyces coelicolor originally discovered by gene sequence analysis. Surprisingly, this tetrapeptide is assembled by a trimodular nonribosomal peptide synthetase.

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Figure 1: A nonclassical nonribosomal peptide synthetase mechanism assembles coelichelin in S. coelicolor.

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Bachmann, B. Decoding chemical structures from genomes. Nat Chem Biol 1, 244–245 (2005). https://doi.org/10.1038/nchembio1005-244

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