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Relaxed specificity in aromatic prenyltransferases

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Prenylation represents a critical step in the biosynthesis of many natural products. A new study reveals how aromatic prenyltransferase enzymes tolerate diverse aromatic polyketides while still controlling the length of prenyl side chains.

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Figure 1: Structure of the aromatic prenyltransferase Orf2, from Streptomyces, complexed with aromatic and prenyl substrates.

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  1. Department of Computer Science and the Genome Center, University of California, Davis, 95616, California, USA

    Patrice Koehl

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  1. Patrice Koehl
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Koehl, P. Relaxed specificity in aromatic prenyltransferases. Nat Chem Biol 1, 71–72 (2005). https://doi.org/10.1038/nchembio0705-71

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