In diseases linked to protein aggregation, the initiation of aggregation can be a critical point in the disease mechanism. New studies in cells expressing huntingtin exon I suggest that the initiation of polyglutamine aggregation proceeds by a simple nucleation mechanism.
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Ingrid McNamara
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Wetzel, R. Nucleation of huntingtin aggregation in cells. Nat Chem Biol 2, 297–298 (2006). https://doi.org/10.1038/nchembio0606-297
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DOI: https://doi.org/10.1038/nchembio0606-297
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