Enzymes have long captivated biologists and chemists by performing difficult reactions rapidly and selectively in aqueous environments. The designs of enzymes catalyzing a retro-aldol reaction and a Kemp elimination demonstrate that complex, biochemically novel reactions can be achieved using cutting-edge computational methods.
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Nanda, V. Do-it-yourself enzymes. Nat Chem Biol 4, 273–275 (2008). https://doi.org/10.1038/nchembio0508-273
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DOI: https://doi.org/10.1038/nchembio0508-273
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