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Signal transduction via unstructured protein conduits

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Signaling via phosphorylation-regulated protein-protein interactions often involves flexible or unstructured proteins. Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.

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Figure 1: The p27Kip1 signaling conduit.

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Authors and Affiliations

  1. A. Keith Dunker and Vladimir N. Uversky are in the Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 410 W. 10th St., Suite 5000, Indianapolis, Indiana 46202, USA. kedunker@iupui.edu vuversky@iupui.edu,

    A Keith Dunker & Vladimir N Uversky

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  1. A Keith Dunker
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  2. Vladimir N Uversky
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Dunker, A., Uversky, V. Signal transduction via unstructured protein conduits. Nat Chem Biol 4, 229–230 (2008). https://doi.org/10.1038/nchembio0408-229

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