Syntheses of natural product–like compound libraries with high scaffold diversity have proven hard to develop. A strategy employing metathesis cascades to 'zip up' a set of unsaturated building blocks differently connected by variable linkers demonstrates that over 80 distinct scaffold classes can be synthesized in one go.
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Waldmann, H. Killing 84 birds with one stone. Nat Chem Biol 5, 76–77 (2009). https://doi.org/10.1038/nchembio0209-76
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DOI: https://doi.org/10.1038/nchembio0209-76
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