Though the chemical mechanisms of many enzymes have been elucidated, the mechanisms by which specificity and rate acceleration are achieved remain less explored. A new study suggests that physically controlled processes, such as active site access and organization, are rate limiting for enzymatic catalysis.
References
Henzler-Wildman, K.A. et al. Nature advance online publication, 18 November 2007 (doi:10.1038/nature06410).
Fenimore, P.W., Frauenfelder, H., McMahon, B.H. & Parak, F.G. Proc. Natl. Acad. Sci. USA 99, 16047–16051 (2002).
Wolf-Watz, M. et al. Nat. Struct. Mol. Biol. 11, 945–949 (2004).
Fenimore, P.W., Frauenfelder, H., McMahon, B.H. & Young, R.D. Proc. Natl. Acad. Sci. USA 101, 14408–14413 (2004).
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Frauenfelder, H. What determines the speed limit on enzyme catalysis?. Nat Chem Biol 4, 21–22 (2008). https://doi.org/10.1038/nchembio0108-21
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DOI: https://doi.org/10.1038/nchembio0108-21
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