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Preventing protein secretion with chemical glue

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A small-molecule inhibitor of protein secretion has been found that targets Cdc42, a regulator of the secretory pathway. This compound acts through a previously undescribed mechanism—by recruiting a protein inhibitor.

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Figure 1: A newly discovered means of inhibiting Cdc42 activity and preventing trafficking of proteins from the Golgi to the cell surface.

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  1. Department of Biological Sciences and the Department of Chemistry, Columbia University, Fairchild Center MC2406, 1212 Amsterdam Avenue, New York, 10027, New York, USA

    Brent R Stockwell

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  1. Brent R Stockwell
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Stockwell, B. Preventing protein secretion with chemical glue. Nat Chem Biol 2, 7–8 (2006). https://doi.org/10.1038/nchembio0106-7

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