Skip to main content
Log in

Breaking and entering

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

A new small molecule inhibitor of TNF has an unexpected mechanism: it disrupts the trimeric structure of the protein.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Mechanisms of small-molecule TNF inhibitors.

Rebecca Henretta

References

  1. He, M.M. et al. Science 310, 1022–1025 (2005)

    Article  CAS  Google Scholar 

  2. Toogood, P.L.J. Med. Chem. 45, 1543–1558 (2002).

    Article  CAS  Google Scholar 

  3. Arkin, M.R. & Wells, J.A. Nature Rev. Drug. Disc. 3, 301–317 (2004).

    Article  CAS  Google Scholar 

  4. Samanen, J. Ann. Rep. Med. Chem. 31, 91–100 (1996).

    CAS  Google Scholar 

  5. Oltersdorf, T. et al. Nature 435, 677–681 (2005).

    Article  CAS  Google Scholar 

  6. Braisted, A.C. et al. J. Am. Chem. Soc. 125, 3714–3715 (2003).

    Article  CAS  Google Scholar 

  7. Jones, S. & Thornton, J.M. Proc. Natl. Acad. Sci. USA 93, 13–20 (1996).

    Article  CAS  Google Scholar 

  8. Bogan, A.A. & Thorn, K.S.J. Mol. Biol. 280, 1–9 (1998).

    Article  CAS  Google Scholar 

  9. Blasko, E. et al. J. Biol. Chem. 277, 295–302 (2002).

    Article  CAS  Google Scholar 

  10. Capps, K.J. et al. Bioorg. Med. Chem. Lett. 15, 2840–2844 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clackson, T. Breaking and entering. Nat Chem Biol 2, 14–15 (2006). https://doi.org/10.1038/nchembio0106-14

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0106-14

  • Springer Nature America, Inc.

Navigation