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Protein misfolding

Tracking a toxic polyQ epitope

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The monoclonal antibody 3B5H10 that recognizes diffuse mutant huntingtin predicts cell death in primary striatal neurons. Biochemical and biophysical analyses reveal that the 3B5H10 epitope is exposed in a monomeric state, identifying this specific conformation as a toxic agent in Huntington's disease.

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Figure 1: Identification of toxic epitope of expanded polyQ in live neurons.

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Authors and Affiliations

  1. Motomasa Tanaka is in the Laboratory for Protein Conformation Diseases at RIKEN Brain Science Institute, Saitama, Japan.,

    Motomasa Tanaka

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  1. Motomasa Tanaka
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Correspondence to Motomasa Tanaka.

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The author declares no competing financial interests.

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Tanaka, M. Tracking a toxic polyQ epitope. Nat Chem Biol 7, 861–862 (2011). https://doi.org/10.1038/nchembio.718

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  • DOI: https://doi.org/10.1038/nchembio.718

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