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Signal transduction

STIM1 senses both Ca2+ and heat

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STIM proteins are ubiquitous endoplasmic reticulum Ca2+ sensors that rapidly translocate to couple with 'store-operated' Orai Ca2+ channels when luminal Ca2+ levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.

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Figure 1: STIM1 activation results from either Ca2+ sensing or temperature sensing.

References

  1. Clapham, D.E. Cell 131, 1047–1058 (2007).

    Article  CAS  Google Scholar 

  2. Deng, X., Wang, Y., Zhou, Y., Soboloff, J. & Gill, D.L. J. Biol. Chem. 284, 22501–22505 (2009).

    Article  CAS  Google Scholar 

  3. Collins, S.R. & Meyer, T. Trends Cell Biol. 21, 202–211 (2011).

    Article  CAS  Google Scholar 

  4. Hogan, P.G., Lewis, R.S. & Rao, A. Annu. Rev. Immunol. 28, 491–533 (2010).

    Article  CAS  Google Scholar 

  5. Mancarella, S., Wang, Y. & Gill, D.L. Curr. Biol. 19, R950–R952 (2009).

    Article  CAS  Google Scholar 

  6. Xiao, B., Coste, B., Mathur, J. & Patapoutian, A. Nat. Chem. Biol. 7, 351–358 (2011).

    Article  CAS  Google Scholar 

  7. Park, C.Y. et al. Cell 136, 876–890 (2009).

    Article  CAS  Google Scholar 

  8. Wang, Y., Deng, X. & Gill, D.L. Sci. Signal. 3, pe42 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Hawkins, B.J. et al. J. Cell Biol. 190, 391–405 (2010).

    Article  CAS  Google Scholar 

  10. Wang, Y. et al. Science 330, 105–109 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Youjun Wang and Donald L. Gill are in the Department of Biochemistry, Salvatore Mancarella, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.,

    Salvatore Mancarella, Youjun Wang & Donald L Gill

Authors
  1. Salvatore Mancarella
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  2. Youjun Wang
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  3. Donald L Gill
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Correspondence to Donald L Gill.

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Competing interests

D.L.G. is partly supported by Novartis Institutes for Biomedical Research.

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Mancarella, S., Wang, Y. & Gill, D. STIM1 senses both Ca2+ and heat. Nat Chem Biol 7, 344–345 (2011). https://doi.org/10.1038/nchembio.587

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