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Continuous evolution

Protein evolution at warp speed

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Directed evolution of nucleic acids and proteins in the laboratory can produce many novel phenotypes in a relatively short time frame. A significant enhancement to these techniques allows continuous evolution in special turbidostats and can speed the discovery of proteins with desirable activities.

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Figure 1: The turbidostat used for phage-assisted continuous evolution (PACE) of proteins.

Katie Vicari

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Authors and Affiliations

  1. Niles Lehman is in the Department of Chemistry, Portland State University, Portland, Oregon, USA.,

    Niles Lehman

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  1. Niles Lehman
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Correspondence to Niles Lehman.

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The author declares no competing financial interests.

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Lehman, N. Protein evolution at warp speed. Nat Chem Biol 7, 252–253 (2011). https://doi.org/10.1038/nchembio.568

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  • DOI: https://doi.org/10.1038/nchembio.568

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