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Protein dynamics

Bridging the gap

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Detailed biophysical and biochemical studies provide an exquisite example of how conformational flexibility controls the interaction between an intrinsically disordered protein and its numerous binding partners.

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Figure 1: Schematic showing the subdomains of the kinase inhibitory domain of p21.

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Authors and Affiliations

  1. Gary W. Daughdrill is in the Department of Cell Biology, Microbiology and Molecular Biology and the Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.,

    Gary W Daughdrill

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  1. Gary W Daughdrill
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Correspondence to Gary W Daughdrill.

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Daughdrill, G. Bridging the gap. Nat Chem Biol 7, 193–194 (2011). https://doi.org/10.1038/nchembio.544

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