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Post-translational modifications

S-linked sugars lost and found

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The vast majority of core structures of protein and peptide glycosylation motifs belong to either O-linked or N-linked glycans. A recent publication describes the structure and biosynthesis of an unusual S-linked glycan linkage in the antibacterial glycopeptide sublancin.

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Figure 1: Glycan structures old and new.

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Authors and Affiliations

  1. Róbert Šardzík, Peter Both and Sabine L. Flitsch are at Manchester Interdisciplinary Biocenter & School of Chemistry, The University of Manchester, Manchester, UK.,

    Róbert Šardzík, Peter Both & Sabine L Flitsch

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  1. Róbert Šardzík
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  2. Peter Both
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  3. Sabine L Flitsch
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Correspondence to Sabine L Flitsch.

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The authors declare no competing financial interests.

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Šardzík, R., Both, P. & Flitsch, S. S-linked sugars lost and found. Nat Chem Biol 7, 69–70 (2011). https://doi.org/10.1038/nchembio.516

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