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Proteomics

Mapping reactive cysteines

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A new quantitative proteomic approach can identify reactive cysteine residues in native proteins and distinguish them on the basis of reactivity. This resource-rich study offers a useful new technology and is a significant step toward understanding the reactivity and functions of cysteines in cells.

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Figure 1: The isoTOP-ABPP method.

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Authors and Affiliations

  1. Stefano M. Marino and Vadim N. Gladyshev are in the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Stefano M Marino & Vadim N Gladyshev

Authors
  1. Stefano M Marino
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  2. Vadim N Gladyshev
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Correspondence to Vadim N Gladyshev.

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The authors declare no competing financial interests.

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Marino, S., Gladyshev, V. Mapping reactive cysteines. Nat Chem Biol 7, 72–73 (2011). https://doi.org/10.1038/nchembio.513

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