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Drug discovery

New Btk inhibitor holds promise

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The nonreceptor tyrosine kinase Btk has emerged as a new molecular target for the treatment of B cell lymphoma and autoimmune disorders. A newly discovered specific small-molecule Btk inhibitor that uniquely stabilizes Btk in an inactive conformation suppresses inflammation in rheumatoid arthritis.

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Figure 1: Btk is crucially involved in multiple signaling cascades.

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Authors and Affiliations

  1. Rudi W. Hendriks is in the Department of Pulmonary Medicine at the Erasmus Medical Center Rotterdam, the Netherlands.,

    Rudi W Hendriks

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  1. Rudi W Hendriks
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Correspondence to Rudi W Hendriks.

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The author declares no competing financial interests.

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Hendriks, R. New Btk inhibitor holds promise. Nat Chem Biol 7, 4–5 (2011). https://doi.org/10.1038/nchembio.502

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