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Grand Challenge Commentary: The chemistry of a dynamic genome

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In the postsequencing era, chemical biology is uniquely situated to investigate genomic DNA alterations arising through epigenetic modifications, genetic rearrangements or active mutation. These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential.

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Figure 1: The dynamic genome.

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Authors and Affiliations

  1. Rahul M. Kohli is in the Division of Infectious Disease in the Department of Medicine, and the Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Rahul M Kohli

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  1. Rahul M Kohli
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Kohli, R. Grand Challenge Commentary: The chemistry of a dynamic genome. Nat Chem Biol 6, 866–868 (2010). https://doi.org/10.1038/nchembio.471

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