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Non-covalent interactions

Fold globally, bond locally

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Protein structures are considerably stabilized by local interactions. A new computational and structural analysis discovers that n→π* interactions between consecutive residues are stabilizing and ubiquitous in a variety of secondary structures.

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Figure 1: n→π* interactions between adjacent residues are local and restrict protein conformation.

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  1. Neal J. Zondlo is in the Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.,

    Neal J Zondlo

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  1. Neal J Zondlo
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Correspondence to Neal J Zondlo.

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The author declares no competing financial interests.

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Zondlo, N. Fold globally, bond locally. Nat Chem Biol 6, 567–568 (2010). https://doi.org/10.1038/nchembio.413

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