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Cell biology

Manipulating proteostasis

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A new study fulfills a central goal of post-genomic medicine, the treatment of inherited loss-of-function disorders not by correcting a genetic mutation but by augmenting the efficiency with which the nascent mutant gene product undergoes conformational maturation and is deployed to its site of action.

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Figure 1: The flow of inherited genetic information (from the genome to the deployed protein) is depicted by vertical green arrows.

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  1. Richard N. Sifers is at Baylor College of Medicine, Houston, Texas, USA.,

    Richard N Sifers

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  1. Richard N Sifers
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Correspondence to Richard N Sifers.

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Sifers, R. Manipulating proteostasis. Nat Chem Biol 6, 400–401 (2010). https://doi.org/10.1038/nchembio.374

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