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PI couples voltage to catalysis

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Functionally coupled motions between the voltage-sensing and the phosphatidylinositol phosphatase domains of the sea squirt protein Ci-VSP is mediated by PI(4,5)P2 binding to the intervening linker, shedding light on the function of an unusual voltage-sensing protein.

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Figure 1: Structures of a voltage-gated ion channel, Ci-VSP and PTEN.

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Authors and Affiliations

  1. Yasushi Okamura is in the Department of Physiology and the Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.,

    Yasushi Okamura

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  1. Yasushi Okamura
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Correspondence to Yasushi Okamura.

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The author declares no competing financial interests.

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Okamura, Y. PI couples voltage to catalysis. Nat Chem Biol 6, 315–316 (2010). https://doi.org/10.1038/nchembio.358

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  • DOI: https://doi.org/10.1038/nchembio.358

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