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RNA structure

A LASER-focused view into cells

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RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.

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Figure 1: LASER detects tertiary structure formation and protein binding.

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Authors and Affiliations

  1. Department of Chemistry and the Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA

    Philip C Bevilacqua

  2. Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA

    Sarah M Assmann

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  1. Philip C Bevilacqua
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  2. Sarah M Assmann
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Correspondence to Philip C Bevilacqua or Sarah M Assmann.

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The authors declare no competing financial interests.

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Bevilacqua, P., Assmann, S. A LASER-focused view into cells. Nat Chem Biol 14, 200–201 (2018). https://doi.org/10.1038/nchembio.2570

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