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Notch signaling

A sweet strategy

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Glycosylation of Notch receptors regulates ligand-induced Notch signaling, which is essential for normal development in animals. Fucose analogs targeting Notch glycosylation serve as ligand-specific Notch inhibitors and facilitate the understanding of how O-glycan regulates Notch–ligand interactions.

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Figure 1: Targeting O-fucose using 6-alkynyl and 6-alkenyl fucose.

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Authors and Affiliations

  1. Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Tetsuya Okajima

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  1. Tetsuya Okajima
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Correspondence to Tetsuya Okajima.

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The author declares no competing financial interests.

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Okajima, T. A sweet strategy. Nat Chem Biol 14, 3–4 (2018). https://doi.org/10.1038/nchembio.2532

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  • DOI: https://doi.org/10.1038/nchembio.2532

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