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Kinetochore regulation

Let there be light

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Kinetochores form the critical interface with spindle microtubules that accounts for chromosome movement and segregation fidelity during mitosis. Spatial and temporal control of motor protein and checkpoint signaling at kinetochores is now possible with a new set of optogenetic tools.

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Figure 1: Optogenetic control of kinetochore function.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal

    Ana C Figueiredo

  2. Department of Biomedicine, Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde (i3S), Faculdade de Medicina Universidade do Porto, Porto, Portugal

    Helder Maiato

  3. Whitman Center, Marine Biological Laboratory, Woods Hole, Massachusetts, USA

    Helder Maiato

Authors
  1. Ana C Figueiredo
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  2. Helder Maiato
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Correspondence to Helder Maiato.

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The authors declare no competing financial interests.

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Figueiredo, A., Maiato, H. Let there be light. Nat Chem Biol 13, 1058–1059 (2017). https://doi.org/10.1038/nchembio.2464

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