The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.
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Bowers, A. Methylating mushrooms. Nat Chem Biol 13, 821–822 (2017). https://doi.org/10.1038/nchembio.2437
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DOI: https://doi.org/10.1038/nchembio.2437
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