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Ferroptosis

Oxidized PEs trigger death

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Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

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Figure 1: Mechanism of ferroptosis execution and generation of oxidized phosphatidylethanolamines.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Katharina D'Herde is at the Department of Basic Medical Sciences, and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.,

    Katharina D'Herde

  2. Dmitri V. Krysko is at the Department of Basic Medical Sciences and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.,

    Dmitri V Krysko

Authors
  1. Katharina D'Herde
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  2. Dmitri V Krysko
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Correspondence to Dmitri V Krysko.

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The authors declare no competing financial interests.

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D'Herde, K., Krysko, D. Oxidized PEs trigger death. Nat Chem Biol 13, 4–5 (2017). https://doi.org/10.1038/nchembio.2261

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