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DNA-catalyzed hydrolysis of DNA phosphodiesters

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Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn2+ and Mn2+ ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized.

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Figure 1: Deoxyribozyme-catalyzed cleavage of DNA.

Katie Vicari

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Authors and Affiliations

  1. Mostafa I. Fekry is in the Departments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri, USA.,

    Mostafa I Fekry

  2. Kent S. Gates is in the Departments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri, USA.,

    Kent S Gates

Authors
  1. Mostafa I Fekry
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  2. Kent S Gates
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Correspondence to Kent S Gates.

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Fekry, M., Gates, K. DNA-catalyzed hydrolysis of DNA phosphodiesters. Nat Chem Biol 5, 710–711 (2009). https://doi.org/10.1038/nchembio.224

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