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Metabolic engineering

Biosensors get the green light

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A novel approach recruits the largest prokaryotic family of ligand-induced transcriptional regulators to develop a new class of biosensors in yeast based on transcriptional activation, vastly expanding the repertoire of biosensors that could function in eukaryotic hosts.

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Figure 1: General biosensor design based on LTTRs.

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Authors and Affiliations

  1. Sarah K. Hammer is at the Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA.,

    Sarah K Hammer

  2. José L. Avalos is at the Department of Chemical and Biological Engineering, and the Department of Molecular Biology, the Andlinger Center for Energy and the Environment, Princeton University, Princeton, New Jersey, USA.,

    José L Avalos

Authors
  1. Sarah K Hammer
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  2. José L Avalos
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Correspondence to José L Avalos.

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The authors declare no competing financial interests.

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Hammer, S., Avalos, J. Biosensors get the green light. Nat Chem Biol 12, 894–895 (2016). https://doi.org/10.1038/nchembio.2214

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  • DOI: https://doi.org/10.1038/nchembio.2214

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