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Single-molecule biophysics

TALEs spin along, but not around

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TALE proteins search for target sequences along a DNA substrate in a uniquely one-dimensional and non-rotating fashion.

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Figure 1: Model of a TALE transitioning between search, recognition and binding modes.

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Authors and Affiliations

  1. Sebastian Becker and Jens Boch are at the Institute of Plant Genetics, Leibniz University Hannover, Hannover, Germany.,

    Sebastian Becker & Jens Boch

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  1. Sebastian Becker
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  2. Jens Boch
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Correspondence to Jens Boch.

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Competing interests

J.B. is a part owner of a patent governing the use of TALEs.

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Becker, S., Boch, J. TALEs spin along, but not around. Nat Chem Biol 12, 766–768 (2016). https://doi.org/10.1038/nchembio.2182

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