Glucose metabolism has long been thought to operate with exquisite specificity and near-optimal efficiency. New findings show, however, that two glycolytic enzymes produce minor products that inhibit other enzymes involved in central carbon metabolism unless they are further metabolized by a novel enzyme.
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References
Liberti, M.V. & Locasale, J.W. Trends Biochem. Sci. 41, 211–218 (2016).
Bar-Even, A., Flamholz, A., Noor, E. & Milo, R. Nat. Chem. Biol. 8, 509–517 (2012).
Rabinowitz, J.D. & Vastag, L. Nat. Chem. Biol. 8, 497–501 (2012).
Collard, F. et al. Nat. Chem. Biol. 12, 601–607 (2016).
Madhukar, N.S., Warmoes, M.O. & Locasale, J.W. PLoS One 10, e0117131 (2015).
Shestov, A.A. et al. eLife 3, e03342 (2014).
Intlekofer, A.M. et al. Cell Metab. 22, 304–311 (2015).
Fan, J. et al. ACS Chem. Biol. 10, 510–516 (2015).
Okar, D.A. et al. Trends Biochem. Sci. 26, 30–35 (2001).
Kim, S.R. et al. Appl. Environ. Microbiol. 81, 1601–1609 (2015).
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Liberti, M., Locasale, J. A new layer of glycolysis. Nat Chem Biol 12, 577–578 (2016). https://doi.org/10.1038/nchembio.2133
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DOI: https://doi.org/10.1038/nchembio.2133
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