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Cell division

TIPs for shaping Aurora B activity

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Cdk1 links mitotic entry to faithful chromosome segregation by activating the acetyltransferase TIP60. Acetylation of Aurora B kinase by TIP60 protects Aurora B's activation loop from dephosphorylation by the PP2A phosphatase to ensure robust Aurora B activation.

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Figure 1: Cdk1 couples mitotic entry to Aurora B activation.

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Authors and Affiliations

  1. George Zachos is in the Department of Biology, University of Crete, Heraklion, Greece.,

    George Zachos

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  1. George Zachos
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Correspondence to George Zachos.

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The author declares no competing financial interests.

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Zachos, G. TIPs for shaping Aurora B activity. Nat Chem Biol 12, 204–205 (2016). https://doi.org/10.1038/nchembio.2041

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