Selecting compounds for the chemical library is the foundation of high-throughput screening (HTS). After some years and multiple HTS campaigns, many molecules in the Novartis and NIH Molecular Libraries Program screening collections have never been found to be active. An in-depth exploration of the bioactivity of this 'dark matter' does in fact reveal some compounds of interest.
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Macarron, R. How dark is HTS dark matter?. Nat Chem Biol 11, 904–905 (2015). https://doi.org/10.1038/nchembio.1937
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DOI: https://doi.org/10.1038/nchembio.1937
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