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Probing the epigenome

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Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.

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Figure 1: Leveling the landscape of epigenetics research (a,b).
Figure 2: Epigenetic chemical probes are extensively used.
Figure 3: Chemical biology tools for epigenetic drug discovery.

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Author information

Authors and Affiliations

  1. Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

    Andrea Huston, Cheryl H Arrowsmith & Matthieu Schapira

  2. Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

    Cheryl H Arrowsmith

  3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Cheryl H Arrowsmith

  4. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK

    Stefan Knapp

  5. Target Discovery Institute, University of Oxford, Oxford, UK

    Stefan Knapp

  6. Structural Genomic Consortium, University of Oxford, Oxford, UK

    Stefan Knapp

  7. Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

    Stefan Knapp

  8. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

    Matthieu Schapira

Authors
  1. Andrea Huston
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  2. Cheryl H Arrowsmith
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  3. Stefan Knapp
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  4. Matthieu Schapira
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Corresponding authors

Correspondence to Stefan Knapp or Matthieu Schapira.

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The authors declare no competing financial interests.

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Supplementary Text and Figures

Supplementary Figures 1–2 and Supplementary Tables 1–2 (PDF 1504 kb)

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Huston, A., Arrowsmith, C., Knapp, S. et al. Probing the epigenome. Nat Chem Biol 11, 542–545 (2015). https://doi.org/10.1038/nchembio.1871

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