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Kinase inhibitors

An allosteric add-on

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Development of highly specific kinase inhibitors has been a long-standing challenge in chemical biology. The structural and mechanistic characterization of an Erk1/2 kinase inhibitor provides new strategies to develop specific kinase inhibitors by targeting a binding pocket adjacent to the ATP binding site.

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Figure 1: Comparison of binding modes for small-molecule protein kinase inhibitors.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Zachariah H. Foda and Markus A. Seeliger are in the Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, New York, USA.,

    Zachariah H Foda & Markus A Seeliger

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  1. Zachariah H Foda
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  2. Markus A Seeliger
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Correspondence to Markus A Seeliger.

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The authors declare no competing financial interests.

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Foda, Z., Seeliger, M. An allosteric add-on. Nat Chem Biol 10, 796–797 (2014). https://doi.org/10.1038/nchembio.1630

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