Skip to main content
SpringerLink
Log in

Pluripotency

Citrullination unravels stem cells

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases in development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: PAD4 is a regulator of pluripotency gene expression through the conversion of arginine to citrulline in histones.

References

  1. Bicker, K.L. & Thompson, P.R. Biopolymers 99, 155–163 (2013).

    Article  CAS  Google Scholar 

  2. Kaplan, M.J. & Radic, M. J. Immunol. 189, 2689–2695 (2012).

    Article  CAS  Google Scholar 

  3. Cherrington, B.D. et al. PLoS ONE 7, e41242 (2012).

    Article  CAS  Google Scholar 

  4. Cuthbert, G.L. et al. Cell 118, 545–553 (2004).

    Article  CAS  Google Scholar 

  5. Yao, H. et al. J. Biol. Chem. 283, 20060–20068 (2008).

    Article  CAS  Google Scholar 

  6. Sharma, P. et al. PLoS Genet. 8, e1002934 (2012).

    Article  CAS  Google Scholar 

  7. Dwivedi, N. et al. FASEB J. doi:10.1096/fj.13-247254 (2014).

  8. Christophorou, M.A. et al. Nature 507, 104–108 (2014).

    Article  CAS  Google Scholar 

  9. Luo, Y. et al. Biochemistry 45, 11727–11736 (2006).

    Article  CAS  Google Scholar 

  10. Jones, J.E. et al. ACS Chem. Biol. 7, 160–165 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Daniel J. Slade, Venkataraman Subramanian and Paul R. Thompson are at the Scripps Research Institute, Jupiter, Florida, USA.,

    Daniel J Slade, Venkataraman Subramanian & Paul R Thompson

Authors
  1. Daniel J Slade
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Venkataraman Subramanian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul R Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paul R Thompson.

Ethics declarations

Competing interests

P.R.T. is a cofounder and consultant for Padlock Therapeutics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Slade, D., Subramanian, V. & Thompson, P. Citrullination unravels stem cells. Nat Chem Biol 10, 327–328 (2014). https://doi.org/10.1038/nchembio.1504

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1504

  • Springer Nature America, Inc.

Search

Navigation