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Protein self-assembly intermediates

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Proteins can self-assemble into functional states, or they can end up as aberrant and sometimes toxic aggregates. Metastable intermediate states are often detected in these processes, and their structural characterization provides vital information about the balance between functional and pathological behavior in living systems.

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Figure 1: Schematic view of the various metastable and stable states in protein self-assembly.

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Authors and Affiliations

  1. Michele Vendruscolo and Christopher M. Dobson are at the Department of Chemistry, University of Cambridge, Cambridge, UK.,

    Michele Vendruscolo & Christopher M Dobson

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  1. Michele Vendruscolo
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  2. Christopher M Dobson
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Correspondence to Michele Vendruscolo or Christopher M Dobson.

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Vendruscolo, M., Dobson, C. Protein self-assembly intermediates. Nat Chem Biol 9, 216–217 (2013). https://doi.org/10.1038/nchembio.1210

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