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Oxysterols detour to neurodevelopment

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Cholic acid and 24(S),25-epoxycholesterol are oxysterols detected in the developing mesencephalic tissue and selectively regulate the production of either the red nucleus or dopaminergic neurons via activation of the liver X receptors.

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Figure 1: Oxysterol functions in midbrain neurons.

Katie Vicari

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Correspondence to Vania Broccoli.

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Broccoli, V., Caiazzo, M. Oxysterols detour to neurodevelopment. Nat Chem Biol 9, 70–71 (2013). https://doi.org/10.1038/nchembio.1165

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